Document Type
Article
Publication Date
2021
Publication Title
International Journal of Molecular Sciences
Volume
22
Issue
11
Pages
1-16
DOI
10.3390/ijms22115909
Abstract
We developed two models of chemically induced chronic lung injury and pulmonary fibrosis in mice (intratracheally administered hydrochloric acid (HCl) and intratracheally administered nitrogen mustard (NM)) and investigated male-female differences. Female mice exhibited higher 30-day survival and less weight loss than male mice. Thirty days after the instillation of either HCl or NM, bronchoalveolar lavage fluid displayed a persistent, mild inflammatory response, but with higher white blood cell numbers and total protein content in males vs. females. Furthermore, females exhibited less collagen deposition, milder pulmonary fibrosis, and lower Ashcroft scores. After instillation of either HCl or NM, all animals displayed increased values of phosphorylated (activated) Heat Shock Protein 90, which plays a crucial role in the alveolar wound-healing processes; however, females presented lower activation of both transforming growth factor-β (TGF-β) signaling pathways: ERK and SMAD. We propose that female mice are protected from chronic complications of a single exposure to either HCl or NM through a lesser activation of TGF-β and downstream signaling. The understanding of the molecular mechanisms that confer a protective effect in females could help develop new, gender-specific therapeutics for IPF.
Original Publication Citation
Solopov, P., Colunga Biancatelli, R. M. L., Dimitropoulou, C., & Catravas, J. D. (2021). Sex-related differences in murine models of chemically induced pulmonary fibrosis. International Journal of Molecular Sciences, 22(11), Article 5909, 1-16. https://doi.org/10.3390/ijms22115909
Repository Citation
Solopov, Pavel; Biancatelli, Ruben Manuel Luciano Colunga; Dimitropoulou, Christiana; and Catravas, John D., "Sex-Related Differences in Murine Models of Chemically Induced Pulmonary Fibrosis" (2021). Bioelectrics Publications. 306.
https://digitalcommons.odu.edu/bioelectrics_pubs/306
ORCID
0000-0002-1705-027X (Solopov), 0000-0002-1174-3876 (Biancatelli),
Included in
Animal Diseases Commons, Bioelectrical and Neuroengineering Commons, Respiratory System Commons, Respiratory Tract Diseases Commons
Comments
© 2021 The Authors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Publisher's version available at: https://doi.org/10.3390/ijms22115909