Document Type

Article

Publication Date

2021

Publication Title

SIMUL 2021, The Thirteenth International Conference on Advances in System Simulation

Pages

8-13

Conference Name

SIMUL 2021, The Thirteenth International Conference on Advances in System Simulation, 3-7 October 2021, Barcelona, Spain

Abstract

Long QT Syndrome (LQTS) is associated with cardiac arrhythmia and sudden cardiac death. The Long QT Type 2 (LQT2) phenotype, which accounts for 35–40 % of all LQTS patients, is caused by mutations in HERG gene. The mechanisms of arrhythmia in presence of LQT2 conditions are not fully understood. We utilized anatomically and electrophysiologically realistic numerical simulations to elucidate the mechanisms of arrhythmia initiation in presence of blockade in rapid component of delayed rectifier potassium current, IKr. We utilized a 3D finite element model of rabbit ventricles integrated with His-purkinje network to simulate whole heart response to LQT2 conditions. We observed that the loss of IKr function produced more severe phenotype in cardiac Purkinje cells than that in ventricular myocytes. Our simulations also revealed that arrhythmia susceptibility is increased when there is a loss of IKr functionality. Our multi-scale computer modeling results provide useful insights into the potential mechanisms of arrhythmia in LQT2 conditions.

Rights

© IARIA, 2021. All rights reserved.

Included with the kind written permission of the copyright holder.

Original Publication Citation

Owusu-Mensah, A., Lam, V., Tsevi, B., Audette, M., & Deo, M. (2021). In silico investigation of cardiac arrhythmia susceptibility in long QT phenotype. In F. Herrmann, M. Popescu, & M. A. Audette (Eds.), SIMUL 2021, The Thirteenth International Conference on Advances in System Simulation (pp. 8-13). IARIA Press (Xpert Publishing Services). https://www.thinkmind.org/library/SIMUL/SIMUL_2021/simul_2021_1_20_58005.html

ORCID

0000-0002-9770-3356 (Owusu-Mensah), 0000-0003-0011-1731 (Audette)

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