Document Type

Article

Publication Date

2026

DOI

10.18502/fid.v23i30.22883

Publication Title

Frontiers in Dentistry

Volume

23

Issue

30

Pages

1-13

Abstract

Developing a laboratory-grown construct integrating viable bone and oral mucosal tissues with strong adhesion between the hard and soft tissue layers presents a significant challenge. This engineered tissue construct holds promise as a versatile graft material for diverse oral surgeries and as an in vitro model for evaluating dental materials, dental implants, and oral healthcare products, potentially replacing the need for in vivo studies. Additionally, it offers a valuable tool for investigating various aspects of oral diseases and evaluating the efficacy of different treatments, eliminating the need for animal models. The success of such osteo-mucosal constructs depends on achieving proper adhesion between the bone and connective tissue layers, prompting researchers to conduct studies exploring interlayer adhesion mechanisms. This review provides a comprehensive overview of advances in osteo-mucosal models, conducted through a search of articles published in journals indexed in PubMed, ScienceDirect, Scopus, and Google Scholar databases from January 2010 to January 2024. First, we outline the methods used to construct various components of osteo-mucosal models, including the materials and fabrication techniques. Next, we provide a detailed discussion of the adhesion methods employed. Lastly, we compare the effectiveness of each adhesion method by summarizing the results of cell viability studies, which are crucial for the success of tissue regeneration. This review provides a comprehensive understanding of recent advancements in osteo-mucosal models and their interfacial adhesion, paving the way for promising clinical applications.

Rights

© 2026 The Authors.

This work is published as an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License. Non-commercial uses of the work are permitted, provided the original work is properly cited.

Original Publication Citation

Mihandoust, S., Seyed-Monir, A., Ghavami-Lahiji, M., Moharamzadeh, K., & Tayebi, L. (2026). Engineering osteo-mucosal constructs: A review of adhesion mechanisms and innovations. Frontiers in Dentistry, 23(30), 1-13. https://doi.org/10.18502/fid.v23i30.22883

ORCID

0000-0003-1947-5658 (Tayebi)

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