Document Type
Article
Publication Date
2023
DOI
10.1016/j.xjmad.2023.100026
Publication Title
Journal of Mood & Anxiety Disorders
Volume
3
Pages
100026 (1-4)
Abstract
Advanced epigenetic age is associated with psychopathology and may help to explain the link between psychopathology and physical health morbidity and mortality. Using a longitudinal sample of 171 trauma-exposed Veterans, we modeled the rate of change in epigenetic age across two time points (averaging 5.58 years apart) using two epigenetic age algorithms (GrimAge and Horvath) and tested associations with posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and depression. Results showed that PTSD (β = .199) and AUD (β = .186) were associated with a quickened pace of epigenetic aging over time (ps < .021). Results replicate and extend prior work and offer foundational support for identifying interventions that slow the pace of biological aging among those with psychopathology.
Rights
© 2023 The Authors.
This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License.
Original Publication Citation
Hawn, S. E., Zhao, X., Miller, M. W., Wallander, S., Govan, C., Stone, A., Schichman, S. A., Logue, M. W., & Wolf, E. J. (2023). PTSD and alcohol use disorders predict the pace of cellular aging. Journal of Mood & Anxiety Disorders, 3, 1-4, Article 100026. https://doi.org/10.1016/j.xjmad.2023.100026
Repository Citation
Hawn, Sage E.; Zhao, Xiang; Miller, Mark W.; Wallander, Sara; Govan, Christine; Stone, Anjanette; Schichman, Steven A.; Logue, Mark W.; and Wolf, Erika J., "PTSD and Alcohol Use Disorders Predict the Pace of Cellular Aging" (2023). Psychology Faculty Publications. 165.
https://digitalcommons.odu.edu/psychology_fac_pubs/165
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