Event Title

Electrochemical Synthesis and Optimization of Magnetic Nanoparticles to Induce Cell-Specific Apoptosis in Metastatic Glioblastoma

Location

Old Dominion University, Learning Commons at Perry Library, West Foyer

Start Date

8-4-2017 8:30 AM

End Date

8-4-2017 10:00 AM

Description

Superparamagnetic Iron Oxide Nanoparticles (SPIONS) have been at the forefront of novel theranostic oncology research for the last two decades. Though intracellular SPION-induced magnetic hyperthermia is more cell-specific and has a greater biocompatibility than chemotherapy, one of the most significant problems with this method is the impossibility to control SPION distribution throughout the cell. As the initial portion of a 2-step solution, this paper proposes a simple redox reaction that regulates SPION size by controlling the [H2O] in solution. The reaction allows a maximal particle size (MPS) to be formed while maintaining a single domain magnetic state. This MPS will release a significant amount of energy when exposed to an external alternating magnetic field; enough to denature targeted intracellular structures. Transmission electron microscopy studies determined that a 100% H2O solution produced SPION’s with an average diameter of 58.0 +/- 6.74 nm. As the [H2O] decreased, so did the diameters of the SPION’s, down to 4.40 +/- 1.40 nm in the 3% H2O solution. A novel form of Rayleigh’s equation was also derived that predicted, with great accuracy (%ee=6.60%) but limited application, SPION diameter through utilization of light scattering data.

Presentation Type

Poster

This document is currently not available here.

Share

COinS
 
Apr 8th, 8:30 AM Apr 8th, 10:00 AM

Electrochemical Synthesis and Optimization of Magnetic Nanoparticles to Induce Cell-Specific Apoptosis in Metastatic Glioblastoma

Old Dominion University, Learning Commons at Perry Library, West Foyer

Superparamagnetic Iron Oxide Nanoparticles (SPIONS) have been at the forefront of novel theranostic oncology research for the last two decades. Though intracellular SPION-induced magnetic hyperthermia is more cell-specific and has a greater biocompatibility than chemotherapy, one of the most significant problems with this method is the impossibility to control SPION distribution throughout the cell. As the initial portion of a 2-step solution, this paper proposes a simple redox reaction that regulates SPION size by controlling the [H2O] in solution. The reaction allows a maximal particle size (MPS) to be formed while maintaining a single domain magnetic state. This MPS will release a significant amount of energy when exposed to an external alternating magnetic field; enough to denature targeted intracellular structures. Transmission electron microscopy studies determined that a 100% H2O solution produced SPION’s with an average diameter of 58.0 +/- 6.74 nm. As the [H2O] decreased, so did the diameters of the SPION’s, down to 4.40 +/- 1.40 nm in the 3% H2O solution. A novel form of Rayleigh’s equation was also derived that predicted, with great accuracy (%ee=6.60%) but limited application, SPION diameter through utilization of light scattering data.