Technology in Cancer Research & Treatment
Interferon α may be used as a single agent therapy for metastatic malignant melanoma or as an adjuvant to chemotherapy. Delivery of interferon α by gene therapy offers an alternative to recombinant protein therapy. Electrically mediated delivery enhances plasmid expression in a number of tissues, for instance skin, liver, muscle and tumors including melanomas. Here we compare the effect of delivery of a plasmid encoding mouse interferon α on growth of visible B16 mouse melanomas following electrically mediated delivery to muscle or directly to the tumor. Intratumoral delivery of interferon α plasmid not only slows melanoma growth, but induces complete, long term, regression. This effect was not observed after intramuscular delivery.
Original Publication Citation
Heller, L. C., Ingram, S. F., Lucas, M. L., Gilbert, R. A., & Heller, R. (2002). Effect of electrically mediated intratumor and intramuscular delivery of a plasmid encoding IFN α on visible B16 mouse melanomas. Technology in Cancer Research Treatment, 1(3), 205-209. doi:10.1177/153303460200100305
Heller, Loree C.; Ingram, Stephanie F.; Lucas, M. Lee; Gilbert, Richard A.; and Heller, Richard, "Effect of Electrically Mediated Intratumor and Intramuscular Delivery of a Plasmid Encoding IFN α on Visible B16 Mouse Melanomas" (2002). Bioelectrics Publications. 108.
0000-0001-8084-0787 (Heller, L.), 0000-0003-1899-3859 (Heller, R.)