Document Type

Article

Publication Date

2-2018

Publication Title

Physics of Plasmas

Volume

25

Issue

2

Pages

023508 (6 pp.)

DOI

10.1063/1.5010724

Abstract

In plasma cancer therapy, the inactivation of cancer cells under plasma treatment is closely related to the reactive oxygen and nitrogen species (RONS) induced by plasmas. Quantitative study on the plasma-induced RONS that related to cancer cells apoptosis is critical for advancing the research of plasma cancer therapy. In this paper, the effects of several reactive species on the inactivation of LP-1 myeloma cancer cells are comparatively studied with variable working gas composition, surrounding gas composition, and discharge power. The results show that helium plasma jet has a higher cell inactivation efficiency than argon plasma jet under the same discharge power. By comparing the concentration of aqueous phase reactive species and the cell inactivation efficiency under different working gases and discharge powers, it is demonstrated that the inactivation efficiency of LP-1 myeloma cancer cells is strongly correlated with the concentration of peroxynitrite (ONOOH/ONOO-). Published by AIP Publishing.

Original Publication Citation

Zeyu, C., Qingjie, C., Chen, C., Dehui, X., Dingxin, L., Chen, H. L., & Kong, M. G. (2018). Inactivation of myeloma cancer cells by helium and argon plasma jets: The effect comparison and the key reactive species. Physics of Plasmas, 25(2), 023508. doi:10.1063/1.5010724

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