Inorganic Chemistry Communications
A novel complex, [Cu(acetylethTSC)Cl]Cl · 0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIᶐ which may account for the observed anti-cancer effects.
Original Publication Citation
Sandhaus, S., Taylor, R., Edwards, T., Huddleston, A., Wooten, Y., Venkatraman, R., . . . Holder, A. A. (2016). A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIᶐ. Inorganic Chemistry Communications, 64, 45-49. doi:10.1016/j.inoche.2015.12.013
Sandhaus, Shayna; Taylor, Rosella; Edwards, Tiffany; Huddleston, Alexis; Beebe, Stephen J.; and Holder, Alvin A., "A Novel Copper (II) Complex Identified as a Potent Drug Against Colorectal and Breast Cancer Cells and as a Poison Inhibitor for Human Topoisomerase IIᶐ" (2016). Bioelectrics Publications. 164.
0000-0002-6075-9452 (Beebe), 0000-0001-9618-5297 (Holder)