In Vivo: International Journal of Experimental and Clinical Pathophysiology and Drug Research
A mouse melanoma model was set up with green fluorescent protein (GFP) expression in vivo. With the same energy, long- (1 ms) and short- (300 ns) pulsed electric fields were delivered to two melanomas injected into the same mouse. The tumor growth and green fluorescence were followed up to compare the different treatment efficacy of long and short pulses. After two days post treatment, short pulse-treated tumors showed a significantly lower tumor volume compared with long pulse-treated tumors (n=8, p
Original Publication Citation
Chen, X., Chen, X., Schoenbach, K. H., Zheng, S., & Swanson, R. J. (2011). Comparative study of long-and short-pulsed electric fields for treating melanoma in an in vivo mouse model. In Vivo: International Journal of Experimental and Clinical Pathophysiology and Drug Research, 25(1), 23-27.
Chen, Xinhua; Chen, Xinmei; Schoenbach, Karl H.; Zheng, Shusen; and James Swanson, R., "Comparative Study of Long-and Short-Pulsed Electric Fields for Treating Melanoma in an In Vivo Mouse Model" (2011). Bioelectrics Publications. 231.