Document Type

Article

Publication Date

2005

Publication Title

Physical Review E

Volume

72

Issue

3

Pages

031902

DOI

10.1103/PhysRevE.72.031902

Abstract

A combined MD simulator and time dependent Laplace solver are used to analyze the electrically driven phosphatidylserine externalization process in cells. Time dependent details of nanopore formation at cell membranes in response to a high-intensity (100kV∕cm), ultrashort (10ns) electric pulse are also probed. Our results show that nanosized pores could typically be formed within about 5ns. These predictions are in very good agreement with recent experimental data. It is also demonstrated that defect formation and PS externalization in membranes should begin on the anode side. Finally, the simulations confirm that PS externalization is a nanopore facilitated event, rather than the result of molecular translocation across the trans-membrane energy barrier.

Comments

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Original Publication Citation

Hu, Q., Joshi, R. P., & Schoenbach, K. H. (2005). Simulations of nanopore formation and phosphatidylserine externalization in lipid membranes subjected to a high-intensity, ultrashort electric pulse. Physical Review E, 72(3), 031902. doi:10.1103/PhysRevE.72.031902

ORCID

0000-0001-7867-7773 (Schoenbach)

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