Document Type
Article
Publication Date
2025
DOI
10.1002/slct.202502914
Publication Title
ChemistrySelect
Volume
10
Issue
22
Pages
e02914 (1-9)
Abstract
Here we present a simple and efficient method for fabricating laser-induced graphene (LIG) electrodes for the electrochemical detection of acetaminophen (AAP), a crucial analgesic and antipyretic that can become toxic at elevated concentrations. Unlike conventional sensors that require intricate chemical modifications, the fabricated LIG-based sensor eliminates the need for functionalization, offering a streamlined sensing solution. The LIG electrodes were characterized using scanning electron microscopy, energy-dispersive spectroscopy, and Raman spectroscopy, which confirmed the formation of a highly porous graphene network with excellent purity and conductivity. Cyclic voltammetry analysis with a ferricyanide redox probe revealed a large electroactive surface area of 1.21 cm², indicating enhanced charge transfer efficiency. For AAP detection, square wave voltammetry was employed at an optimized frequency of 10 Hz and amplitude of 70 mV, achieving the widest linear detection range of 10-150 μM (R² = 0.997) and a low detection limit of 1.58 μM. The sensor demonstrated exceptional repeatability over 10 consecutive scans and robust selectivity against common interfering substances, including ascorbic acid and dopamine. The LIG-based sensor was successfully tested in synthetic urine enriched with serum and commercial pharmaceutical tablet samples, demonstrating reliable and accurate AAP quantification for next-generation biomedical and pharmaceutical applications.
Original Publication Citation
Ait Lahcen, A., Sher, M., Ameer, S., & Slaughter, G. (2025). Laser-induced graphene sensor for the electrochemical detection of acetaminophen. ChemistrySelect, 10(22), 1-9, Article e02914. https://doi.org/10.1002/slct.202502914
Repository Citation
Ait Lahcen, A., Sher, M., Ameer, S., & Slaughter, G. (2025). Laser-induced graphene sensor for the electrochemical detection of acetaminophen. ChemistrySelect, 10(22), 1-9, Article e02914. https://doi.org/10.1002/slct.202502914
ORCID
0000-0002-7091-3388 (Ait Lahcen), 0000-0002-4307-091X (Slaughter)
Supporting Information
Included in
Biomedical Engineering and Bioengineering Commons, Medicinal and Pharmaceutical Chemistry Commons, Patient Safety Commons
Comments
© 2025 The Authors.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
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Data Availability Statement: Article states: "The data that support the findings of this study are available from the corresponding author upon reasonable request."