Date of Award

Summer 1976

Document Type


Degree Name

Master of Science (MS)


Biological Sciences



Committee Director

Edgar F. Stillwell

Committee Member

Margaret C. Conrad

Committee Member

Jerry S, Vande Berg

Call Number for Print

Special Collections LD4331.B46 C87


Large artery, pedal small vein, femoral vein and central venous pressures and extremity volume changes were recorded in mongrel dogs in which the hindlimb was perfused at a constant flow. Arterial, pedal venous and femoral venous blood gases were drawn and analyzed for measurements of arterio-venous O2 and CO2 differences. Paw and thigh resistances were calculated. Measurements were repeated following ligation of the iliac and femoral veins, alpha receptor blockade (dibenzyline), and dilation with Vasodilan. Results indicate that ligation of extremity veins results in an active ·increase in total limb resistance below the ligation, an increase in the rate of capillary filtration, and edema formation in the affected limb, Fluid accumulation appears to be detrimental to the exchange of respiratory gases between blood and tissue. The sympathetic reflex response appears to protect against excessive edema formation.


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