Document Type

Article

Publication Date

2013

DOI

10.1155/2013/569751

Publication Title

Clinical and Developmental Immunology

Volume

2013

Pages

569751 (8 pages)

Abstract

The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. Signaling pathway defects have long been hypothesized to participate in the pathology of psoriasis, yet their implication in the altered psoriatic gene expression still remains unclear. Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis. The data are still limited, though, for psoriatic arthritis. This review discusses the current data suggesting a crucial role for p38 MAPK in the pathogenesis of these disorders. Copyright © 2013 Athanasios Mavropoulos et al.

Comments

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,provided the original work is properly cited.

Original Publication Citation

Mavropoulos, A., Rigopoulou, E. I., Liaskos, C., Bogdanos, D. P., & Sakkas, L. I. (2013). The role of p38 MAPK in the aetiopathogenesis of psoriasis and psoriatic arthritis. Clinical and Developmental Immunology, 2013, 569751. doi:10.1155/2013/569751

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