Document Type

Article

Publication Date

1999

DOI

10.1111/j.1574-6968.1999.tb13616.x

Publication Title

FEMS Microbiology Letters

Volume

175

Issue

2

Pages

171-177

Abstract

Streptococcin A-FF22 (SA-FF22) is a type AII linear lantibiotic produced by Streptococcus pyogenes strain FF22. Sequence analysis of an approximate 10 kb region of DNA showed it to contain nine open reading frames arranged in three operons responsible for regulation, biosynthesis and immunity of SA-FF22. This region is organized similarly to the Lactococcus lactis lacticin 481 region, however, unlike lacticin 481, a two-component regulatory system is essential for SA-FF22 production. located immediately downstream of the scn region is a putative transposase gene, the presence of which supports earlier data that indicated a mobile nature to this region. (©) 1999 Published by Elsevier Science B.V. All rights reserved.

Comments

Web of Science: "Free full-text from publisher."

©1999 Published by Elsevier Science B.V. All rights reserved.

Original Publication Citation

McLaughlin, R. E., Ferretti, J. J., & Hynes, W. L. (1999). Nucleotide sequence of the streptococcin A-FF22 lantibiotic regulon: Model for production of the lantibiotic SA-FF22 by strains of Streptococcus pyogenes. FEMS Microbiology Letters, 175(2), 171-177. doi:10.1111/j.1574-6968.1999.tb13616.x

ORCID

0000-0003-3998-7781 (Hynes)

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Microbiology Commons

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