Document Type

Article

Publication Date

2021

DOI

10.1038/s41467-021-23900-8

Publication Title

Nature Communications

Volume

12

Issue

1

Pages

1-17

Abstract

Extracellular vesicles are thought to facilitate pathogen transmission from arthropods to humans and other animals. Here, we reveal that pathogen spreading from arthropods to the mammalian host is multifaceted. Extracellular vesicles from Ixodes scapularis enable tick feeding and promote infection of the mildly virulent rickettsial agent Anaplasma phagocytophilum through the SNARE proteins Vamp33 and Synaptobrevin 2 and dendritic epidermal T cells. However, extracellular vesicles from the tick Dermacentor andersoni mitigate microbial spreading caused by the lethal pathogen Francisella tularensis. Collectively, we establish that tick extracellular vesicles foster distinct outcomes of bacterial infection and assist in vector feeding by acting on skin immunity. Thus, the biology of arthropods should be taken into consideration when developing strategies to control vector-borne diseases.

Comments

© 2021 The Authors

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original authors and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Publisher's version available at: https://doi.org/10.1038/s41467-021-23900-8

Original Publication Citation

Oliva Chávez, A. S., Wang, X., Marnin, L., Archer, N. K., Hammond, H. L., Carroll, E. E. M., . . . Pedra, J. H. F. (2021). Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nature Communications, 12(1), Article 3696, 1-17. https://doi.org/10.1038/s41467-021-23900-8

ORCID

0000-0001-9370-918X (Sonenshine)

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