Date of Award

Summer 1997

Document Type


Degree Name

Doctor of Philosophy (PhD)


Cardiovascular Science

Committee Director

Russell L. Prewitt

Committee Member

Stephen J. Beebe

Committee Member

Mark S. Elliot

Committee Member

Thomas J. Lauterio

Committee Member

Paul H. Ratz


This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control vessels. Neither mean carotid nor local mesenteric arterial pressures changed significantly pre- to post-ligation. The primary flow-mediated force in both vessels was shear stress with possible involvement of acute stretch-induced wall stress in the ileal artery. Significant luminal expansion and medial wall hypertrophy occurred in the ileal and second-order arteries in a time-dependent fashion. Increases in extracellular connective tissue occurred concomitantly with arterial remodeling. Wall thickness to lumen diameter ratios did not change in any vessel at any time when compared to controls, suggesting normalization of flow-induced wall stress through vascular remodeling.


A Dissertation Submitted to the Faculty of Old Dominion University and Eastern Virginia Medical School in Partial Fulfillment of the Requirement for the Degree of Doctor of Philosophy in Biomedical Sciences.