Letter to the Editor
Cancer Gene Therapy
Neoplastic growths represent a unique challenge for the host immune system. As they are indeed derived from self, many of the same mechanisms operating to prevent autoimmunity also provide an umbrella beneath which malignant cells are free to proliferate.1 Central among these immune regulatory boundaries are an influential subset of lymphocytes known as T regs. Hypothesized to exist decades ago, yet eluding definitive characterization until relatively recently, T regs have been demonstrated to play a crucial role in the proper functioning of the immune system as a whole. They may also, however, represent one of the primary obstacles to successful anti-tumor immunotherapies.
Original Publication Citation
Klaiber, N. (2007). Potential for stimulating host anti-tumor immune response via RNAi-mediated local FOXP3 knockdown. Cancer Gene Therapy, 14(5), 519-520. doi:10.1038/sj.cgt.7701043
Klaiber, N., "Potential for Stimulating Host Anti-Tumor Immune Response via RNAi-Mediated Local FOXP3 Knockdown" (2007). Chemistry & Biochemistry Faculty Publications. 131.