3043 (9 pages)
New derivatives of phaeosphaeride A (PPA) were synthesized and characterized. Anti-tumor activity studies were carried out on the HCT-116, PC3, MCF-7, A549, К562, NCI-Н929, Jurkat, THP-1, RPMI8228 tumor cell lines, and on the HEF cell line. All of the compounds synthesized were found to have better efficacy than PPA towards the tumor cell lines mentioned. Compound 6 was potent against six cancer cell lines, HCT-116, PC-3, K562, NCI-H929, Jurkat, and RPMI8226, showing a 47, 13.5, 16, 4, 1.5, and 7-fold increase in anticancer activity comparative to those of etoposide, respectively. Compound 1 possessed selectivity toward the NCI-H929 cell line (IC50 = 1.35 ± 0.69 μM), while product 7 was selective against three cancer cell lines, HCT-116, MCF-7, and NCI-H929, each having IC50 values of 1.65 μM, 1.80 μM and 2.00 μM, respectively.
Original Publication Citation
Abzianidze, V., Beltyukov, P., Zakharenkova, S., Moiseeva, N., Mejia, J., Holder, A., . . . Kuznetsov, V. (2018). Synthesis and biological evaluation of phaeosphaeride a derivatives as antitumor agents. Molecules, 23(11), 3043. doi:10.3390/molecules23113043
Abzianidze, Victoria; Beltyukov, Petr; Zakharenkova, Sofya; Moiseeva, Natalia; Mejia, Jennifer; Holder, Alvin; Trishin, Yuri; Berestetskiy, Alexander; and Kuznetsov, Victor, "Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents" (2018). Chemistry & Biochemistry Faculty Publications. 158.