Photochemistry and Photobiology
Photodynamic therapy (PDT) is a medicinal tool that uses a photosensitiser and a light source to treat several conditions, including cancer. PDT uses reactive oxygen species (ROS) such as cytotoxic singlet oxygen 1O2 to induce cell death in cancer cells. Chemotherapy has historically utilized the cytotoxic effects of many metals, especially transition-metal complexes. However, chemotherapy is a systemic treatment so all cells in a patient's body are exposed to the same cytotoxic effects. Transition metal complexes have also shown high cytotoxicity as PDT agents. PDT is a potential localized method for treating several cancer types by using inorganic complexes as photosensitizing agents. This review covers several in vitro and in vivo studies, as well as clinical trials that reported on the anti-cancer properties of inorganic pharmaceuticals used in PDT against different types of cancer.
Original Publication Citation
Smith, C. B., Days, L. C., Alajroush, D. R., Faye, K., Khodour, Y., Beebe, S. J., & Holder, A. A. (2021). Photodynamic therapy of inorganic complexes for the treatment of cancer. Photochemistry and Photobiology, Article in Press, 1-84. https://doi.org/10.1111/php.13467
0000-0002-6075-9452 (Beebe), 0000-0001-9618-5297 (Holder)
Smith, Chloe B.; Days, Lindsay C.; Alajroush, Duaa R.; Faye, Khadija; Khodour, Yara; Beebe, Stephen J.; and Holder, Alvin, "Photodynamic Therapy of Inorganic Complexes for the Treatment of Cancer" (2021). Chemistry & Biochemistry Faculty Publications. 202.