Document Type

Article

Publication Date

2024

DOI

10.53858/bnas04012939

Publication Title

BIOMED Natural and Applied Science

Volume

4

Issue

1

Pages

29-39

Abstract

Background: The coexistence of lung cancer, chronic obstructive pulmonary disease (COPD), cardiovascular disease (CVD), and pulmonary fibrosis poses significant challenges in clinical management due to shared risk factors, overlapping pathogenic mechanisms, and the complexity of co-managing multimorbid conditions. Smoking, environmental exposures, and genetic predispositions are critical shared risk factors, while common molecular mechanisms such as oxidative stress, chronic inflammation, and aberrant tissue remodeling contribute to the pathogenesis of these diseases. This review comprehensively examines the prevalence, shared mechanisms, and clinical implications of these comorbid conditions, emphasizing the importance of integrated management strategies to improve patient outcomes. We further highlight research gaps and propose future directions for personalized therapeutic approaches.

Rights

© 2024 Umutoni et al.

This is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License (CC BY 4.0) which allows unrestricted download, distribution and reuse as long as the original authors are properly cited.

Original Publication Citation

Umutoni, D., Owolabi, M. S., & Waheed, S. A. (2024). Unraveling the complex interactions among lung cancer, COPD, cardiovascular disease, and pulmonary fibrosis: Overlapping risks, converging pathways, and integrated care approaches. BIOMED Natural and Applied Science, 4(1), 29-39. https://doi.org/10.53858/bnas04012939

ORCID

0000-0002-4546-0153 (Waheed)

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