Journal of Toxicology
The objective of this study was to assess the toxicological effect of exposure to benzo(a)pyrene, B[a]P, on germ cells during spermatogenesis. Mice were exposed to B[a]P at 1, 10, 50, and 100 mg/kg/day for 30 days via oral ingestion. Germ cells, including spermatogonia, spermatocytes, pachytene spermatocytes, and round spermatids, were recovered from testes of mice exposed to B[a]P, while mature spermatozoa were isolated from vas deferens. Reproductive organs were collected and weighed. Apoptotic response of germ cells and mature spermatozoa were qualified using the terminal deoxynucleotidyl transferase mediated deoxy-UTP nick end labeling (TUNEL) assay. B[a]P exposure at
Original Publication Citation
Jeng, H. A., & Bocca, S. M. (2013). Influence of exposure to benzo[a]pyrene on mice testicular germ cells during spermatogenesis. Journal of Toxicology, 2013, 387850. doi: 10.1155/2013/387850
Jeng, Hueiwang Anna and Bocca, Silvina M., "Influence of Exposure to Benzo[a]pyrene on Mice Testicular Germ Cells during Spermatogenesis" (2013). Community & Environmental Health Faculty Publications. 2.