Annals of Clinical Biochemistry
A doubly labelled tracer molecule of glucose, [6,6-2HJglucose, has been used to measure the rate of glucose appearance in blood due to endogenous glucose production (by the liver and kidneysj.l,2 Considered 'non-recirculating', this tracer generally provides a realistic estimate of glucose kinetics.2,3 Used as a dual tracer in conjunction with [l-13C]glucose, the extent of glucose recycling can be quantitated.2-4 but the extent of possible recirculation of a single deuterium atom on newly formed glucose must then be considered.
Original Publication Citation
Horning, M. A., Colberg, S. R., Casazza, G. A., & Brooks, G. A. (2000). Recycling of deuterium from dideuterated glucose during moderate exercise. Annals of Clinical Biochemistry, 37, 540-542. doi:10.1258/0004563001899546
Horning, Michael A.; Colberg, Sheri R.; Casazza, Gretchen A.; and Brooks, George A., "Recycling of Deuterium From Dideuterated Glucose During Moderate Exercise" (2000). Educational Foundations & Leadership Faculty Publications. 52.