ORCID
0000-0002-8991-1737 (Pant)
Document Type
Article
Publication Date
2023
DOI
10.3390/pathogens13010025
Publication Title
Pathogens
Volume
13
Issue
1
Pages
25 (1-17 pp.)
Abstract
Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary tract infections originating from pediatric patients within the southeast region of Virginia, USA. We identified a suite of clinically relevant virulence factors and evaluated their prevalence within these isolates. Five genes (clfA, spA, sbi, scpA, and vwb) with immune-evasive functions were identified in all isolates. MRSA isolates had a greater propensity to be resistant to more antibiotics as well as significantly more likely to carry several virulence factors compared to MSSA strains. Further, the carriage of various genes was found to vary significantly based on the infection type (SSTI, blood, urine).
Original Publication Citation
Cranmer, K. D., Pant, M. D., Quesnel, S., & Sharp, J. A. (2023). Clonal diversity, antibiotic resistance, and virulence factor prevalence of community associated Staphylococcus aureus in southeastern Virginia. Pathogens 2024, 13(1), Article 25. https://doi.org/10.3390/pathogens13010025
Repository Citation
Cranmer, K. D., Pant, M. D., Quesnel, S., & Sharp, J. A. (2023). Clonal diversity, antibiotic resistance, and virulence factor prevalence of community associated Staphylococcus aureus in southeastern Virginia. Pathogens 2024, 13(1), Article 25. https://doi.org/10.3390/pathogens13010025
Included in
Bacterial Infections and Mycoses Commons, Bacteriology Commons, Genomics Commons, Infectious Disease Commons, Pathogenic Microbiology Commons, Public Health Commons
Comments
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).