College of Sciences
Chemistry & Biochemistry
Biomedical Sciences Ph.D. Program
Staphylococcus aureus (S. aureus), is a Gram-positive, facultative anaerobic, biofilm-forming bacterium. It is the leading cause of skin and soft tissue infections (SSTIs) in the United States. The public health impact of S. aureus has been increased by the emergence of Methicillin-resistant Staphylococcus aureus. It has also shown intermediate resistance to Vancomycin, which suggests that full resistance may develop. It is known that hyperglycemia (high blood sugar) from diabetes reduces immune system function. Patients with diabetes experience a greater rate of skin and soft tissue infections. This research explores the effect of increasing glucose concentration on S. aureus response to multiple classes of antibiotics to determine whether hyperglycemia could contribute to treatment failure of diabetic S. aureus SSTIs. Our results support the claim that hyperglycemia will not contribute to treatment failure of diabetic SSTIs while working with different classes of antibiotics.
Staphylococcus aureus, Antibiotics, Glucose supplementation
Bacterial Infections and Mycoses
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Malik, Areej; Chittams-Miles, Alexandra E.; Muratori, Claudia; and Purcell, Erin B., "Study of Glucose Supplementation on Antibiotic Efficacy Against Staphylococcus aureus" (2022). College of Sciences Posters. 3.