In diabetic individuals, increased shunting of circulation away from the skin may exist, contributing to their greater risk for ulcerations and poor cutaneous healing. In a prospective study (1), we previously found a lower skin perfusion during local heating in the foot dorsum of sedentary type 2 diabetic individuals compared with active people without diabetes. This defect was present despite normal increases in skin interstitial nitric oxide (NO), suggesting that NO is either ineffective or not involved (2). A prior bout of maximal exercise also lessened the impaired responsiveness to local heating of the dorsal foot in active type 2 diabetic individuals but not in their sedentary counterparts (3). Thus, this study examined the effect of a single bout of prior moderate cycle exercise on dorsal foot cutaneous perfusion and interstitial NO.
Original Publication Citation
Colberg, S. R., Parson, H. K., Nunnold, T., Holton, D. R., & Vinik, A. I. (2006). Effect of a single bout of prior moderate exercise on cutaneous perfusion in type 2 diabetes. Diabetes Care, 29(10), 2316-2318. doi:10.2337/dc-06-1440
Colberg, Sheri R.; Parson, Henri K.; Nunnold, Tanja; Holton, D. Robb; and Vinik, Aaron I., "Effect of a Single Bout of Prior Moderate Exercise on Cutaneous Perfusion in Type 2 Diabetes" (2006). Human Movement Sciences Faculty Publications. 54.