Date of Award
Doctor of Philosophy (PhD)
Ayodeji O. Demuren
Frederic D. McKenzie
There are a number of disorders that originate from or involve faulty operation of the cardiovascular system. Diseases such as atherosclerosis, diabetes and hypertension can have a debilitating effect on blood flow. This makes the tools for simulating the effects of such diseases on blood flow important. Measures, such as pulse wave velocity, that are generated by models of the cardiovascular system can be important indicators of cardiac health. Although physically measurable, obtaining some parameters comes with a high cost and discomfort to the patient. Models can provide an assessment of many important parameters. The purpose of this project was to create a robust computer generated model of the arterial system. This model is a one-dimensional/Womersley model that used transmission line hemodynamic theory to calculate the blood pressure waveforms and then the Womersley theory to calculate the flow velocity in various areas of the human body. The accuracy of the model was tested using data from eight subjects. The model provided realistic and individualized cardiovascular parameters without requiring any major adjustment to the internal algorithms.
Carter, James C..
"Parameter Estimation of the Arterial System"
(2008). Doctor of Philosophy (PhD), Dissertation, Mechanical Engineering, Old Dominion University, DOI: 10.25777/hsyr-mw37