Document Type

Article

Publication Date

1995

DOI

10.1016/0895-7177(95)00112-f

Publication Title

Mathematical and Computer Modelling

Volume

22

Issue

2

Pages

67-82

Abstract

A mathematical model is used to discuss the effects of cycle-specific chemotherapy. The model includes a constraint equation which describes the effects of the drugs on sensitive normal tissue such as bone marrow. This model investigates both pulsed and piecewise-continuous chemotherapeutic effects and calculates the parameter regions of acceptable dose and period. It also identifies the optimal period needed for maximal tumor reduction. Examples are included concerning the use of growth factors and how they can enhance the cell kill of the chemotherapeutic drugs.

Comments

Elsevier open archive. Copyright © 1995 Published by Elsevier Ltd.

Original Publication Citation

Panetta, J. C., & Adam, J. (1995). A mathematical model of cycle-specific chemotherapy. Mathematical and Computer Modelling, 22(2), 67-82. doi:10.1016/0895-7177(95)00112-f

ORCID

0000-0001-5537-2889 (Adam)

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