Archives of Otolaryngology--Head & Neck Surgery
BACKGROUND: Defects of the facial bone structure are common problems for the facial plastic surgeon. Native type 1 collagen gels (T1CGs) have been shown to mediate repair of facial critical-size defects in rat models.
OBJECTIVE: To evaluate the efficacy of T1CG augmented with insulinlike growth factor (IGF) 1, IGF-2, and a combination of IGF-1 and IGF-2 on the repair of facial critical-size defects in a rodent model.
METHODS: Twenty-four retired male breeder Sprague-Dawley rats were divided into 4 groups of 6 animals. Facial critical-size defects were created by removing the nasalis bones with a bone-cutting drill. Defects were treated with 300 pg of type 1 collagen gel (T1CG), T1CG augmented with 3 microg of IGF-1, T1CG augmented with 3 microg of IGF-2, or T1CG augmented with a combination of 3 microg of IGF-1 and 3 microg of IGF-2. After 30 days the animals were examined at necropsy with precise planimetry, histological analysis of new bone growth, and radiodensitometric analysis of bone thickness.
RESULTS: Radiodensitometric measurements showed that IGF-2 augmentation resulted in greatest osseous healing, with measurements being statistically significant over those of all other groups (P< or = .03). Combination IGF-1 and IGF-2 had osseous healing that was intermediate between IGF-1 augmentation and IGF-2 augmentation alone, with measurements being statistically significant over those of unaugmented gels (P
CONCLUSION: Collagen gels augmented with IGF significantly enhance the osteoconductive repair of nasal critical-size defects in a rodent model, with IGF-2 showing highest efficacy.
Original Publication Citation
Toung, J.S., Ogle, R.C., Morgan, R.F., & Lindsey, W.H. (1999). Insulinlike growth factor 1- and 2-augmented collagen gel repair of facial osseous defects. Archives of Otolaryngology--Head & Neck Surgery, 125(4), 451-455. doi: 10.1001/archotol.125.4.451
Toung, James S.; Ogle, Roy C.; Morgan, Raymond F.; and Lindsey, William H., "Insulinlike Growth Factor 1- and 2-Augmented Collagen Gel Repair of Facial Osseous Defects" (1999). Medical Diagnostics & Translational Sciences Faculty Publications. 2.
Animal Experimentation and Research Commons, Cell Biology Commons, Cells Commons, Hormones, Hormone Substitutes, and Hormone Antagonists Commons, Otolaryngology Commons, Plastic Surgery Commons, Surgery Commons