Document Type

Article

Publication Date

2025

DOI

10.3390/jcm14051632

Publication Title

Journal of Clinical Medicine

Volume

14

Issue

5

Pages

1632 (1-18)

Abstract

Acute respiratory distress syndrome (ARDS) is a heterogeneous group of disease entities that are associated with acute hypoxic respiratory failure and significant morbidity and mortality. With a better understanding and phenotyping of lung injury, novel pathophysiologic mechanisms demonstrate the impact of a patient’s excessive spontaneous breathing effort on perpetuating lung injury. Patient self-inflicted lung injury (P-SILI) is a recently identified phenomenon that delves into the impact of spontaneous breathing on respiratory mechanics in patients with lung injury. While the studies are hypothesis-generating and have been demonstrated in animal and human studies, further clinical trials are needed to identify its impact on ARDS management. The purpose of this review article is to highlight the physiologic mechanisms of P-SILI, novel tools and methods to detect P-SILI, and to review the current literature on non-invasive and invasive respiratory management in patients with ARDS.

Rights

© 2025 by the authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Original Publication Citation

Deshwal, H., Elkhapery, A., Ramanathan, R., Nair, D., Singh, I., Sinha, A., Vashisht, R., & Mukherjee, V. (2025). Patient-self inflicted lung injury (P-SILI): An insight into the pathophysiology of lung injury and management. Journal of Clinical Medicine, 14(5), 1-18, Article 1632. https://doi.org/10.3390/jcm14051632

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