Synthesis and Self-Assembling Properties of Cationic Glycolipids

Title

Synthesis and Self-Assembling Properties of Cationic Glycolipids

College

College of Sciences

Program

Ph.D. Chemistry

Publication Date

3-28-2019

Abstract

Low molecular weight gelators derived from carbohydrates are quite important molecules with a vast amount of applications in many different fields. Monosaccharide based compounds can be modified at different positions with a variety of functional groups to investigate their impact on the gelation process and obtain advanced functional biomaterials. Herein, we have synthesized and studied the gelation properties of several monosaccharides with amino functionalities and some of their respective quaternary ammonium salts. Two series of analogues with variable carbon chain lengths between the amino group and the sugar moiety were examined. Certain derivatives were found to be effective gelators in organic solvents. The amines were converted to their respective ammonium salts with different acids to investigate the possibility of forming spontaneous hydrogels. We also studied other glycolipid based organogelators for their applications in drug delivery and for binding pollutants and dyes. In this presentation, the effect of changing the carbon spacer on both the amines and their salts will be demonstrated; their gelation properties and applications will also be discussed.

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Synthesis and Self-Assembling Properties of Cationic Glycolipids


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