College

College of Sciences

Program

Ph.D. Chemistry

Publication Date

3-28-2019

Abstract

Carbohydrate based low molecular weight gelators (LMWGs) have gained extensive interests due to their interesting applications in the areas of biomedical sciences, environmental remediation and optical electronic devices etc. The gelators can form the gels in a variety of organic solvents (organogels) or in water (hydrogels). Many monosaccharides, for instance, glucose, galactose and glucosamine have been used in the design of LMWGs. These systems have intrinsic advantage of being naturally abundant and biocompatible which makes them suitable candidates for carrying out drug delivery studies and various other biomedical applications. The self-assembly of the sugar molecules is attributed to the non-covalent forces like hydrophobic interactions, hydrogen bonding, π-π interactions and CH-π interactions. Previously we have found that certain D-glucose and D-glucosamine derivatives were effective LMWGs. In this study, we carried out further structure modifications on peracetylated glycosides containing triazole moieties and studied their tendencies of gelation. The influence of distance of triazoles to the sugar anomeric carbon was analyzed. The structure and self assembling properties of two series of glucose and galactose derivatives will be reported.

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Synthesis and Self-Assembling Property of A Series of D-Galactose and D-Glucose Triazole Derivatives


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