Modelling Beta-sheets using Iterative Bézier Surface Fitting on Cryo-EM Density Maps
Description/Abstract/Artist Statement
Cryo-electron microscopy is a powerful technique to produce 3-dimensional images for large molecular complexes. When the resolution of 3-dimensional images is not sufficient to derive atomic structure directly from the image, it is still challenging to interpret the image. In order to model β-strands from medium-resolution images, we propose the use of Bézier surface iteratively to fit a β-sheet image. The proposed method shows improved accuracy in fitting when it was tested using eight cases.
Presentation Type
Event
Location
Learning Commons @ Perry Library, Conference Room 1310
Start Date
2-18-2017 10:15 AM
End Date
2-18-2017 11:15 AM
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Modelling Beta-sheets using Iterative Bézier Surface Fitting on Cryo-EM Density Maps
Learning Commons @ Perry Library, Conference Room 1310
Cryo-electron microscopy is a powerful technique to produce 3-dimensional images for large molecular complexes. When the resolution of 3-dimensional images is not sufficient to derive atomic structure directly from the image, it is still challenging to interpret the image. In order to model β-strands from medium-resolution images, we propose the use of Bézier surface iteratively to fit a β-sheet image. The proposed method shows improved accuracy in fitting when it was tested using eight cases.
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Mentor: Dr. Jing He