Title

Improving Detection of Secondary Structures within Medium Resolution Cryo-EM Density Maps

Presenting Author Name/s

Michael Poteat

Faculty Advisor

Jing He

Presentation Type

Oral Presentation

Disciplines

Bioinformatics | Computer Sciences

Description/Abstract

Cryo-electron microscopy is a biophysical technique in production of electron density maps that are 3-dimensional images. Although atomic structures can be derived from such images at high-resolution, it is still challenging to predict structures when the resolution of the image is at medium resolutions (5-10Å). Although computational methods are available to extract protein secondary structures from a medium-resolution image, they lack sufficient accuracy for structure prediction. This work aims to improve detection of secondary structures such as helices and β-sheets as compared to previous work SSETracer. Detection of these secondary structures is an important prior step for methods that perform further analysis, such as protein sequencing.

Session Title

Biological Sciences 2 Presentations

Location

Learning Commons @ Perry Library Conference Room 1310

Start Date

3-2-2018 10:15 AM

End Date

3-2-2018 11:15 AM

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Feb 3rd, 10:15 AM Feb 3rd, 11:15 AM

Improving Detection of Secondary Structures within Medium Resolution Cryo-EM Density Maps

Learning Commons @ Perry Library Conference Room 1310

Cryo-electron microscopy is a biophysical technique in production of electron density maps that are 3-dimensional images. Although atomic structures can be derived from such images at high-resolution, it is still challenging to predict structures when the resolution of the image is at medium resolutions (5-10Å). Although computational methods are available to extract protein secondary structures from a medium-resolution image, they lack sufficient accuracy for structure prediction. This work aims to improve detection of secondary structures such as helices and β-sheets as compared to previous work SSETracer. Detection of these secondary structures is an important prior step for methods that perform further analysis, such as protein sequencing.