Title

The Effect of Physical Activity on Polychlorinated Biphenyls: A Pilot Study

Description/Abstract/Artist Statement

Polychlorinated Biphenyls (PCBs) are associated with an increased risk of cardiovascular and metabolic disease. PCBs are sequestered in adipose tissue and exercise stimulates lipolysis. However, whether PCB concentrations are altered in habitually active individuals is not well understood. Thus, the purpose of this study was to examine if individuals who participate in high levels of moderate to vigorous physical activity (MVPA) have altered levels of PCBs compared to individuals who participate in low levels of MVPA. Data from the National Health and Nutrition Examination Survey (NHANES) (2003-2004 years) was used 2,697 individuals (Age: High MVPA: 38.67 ± 0.540, Low MVPA: 50.99± 0.618) and BMI: High MVPA: 26.6212 ± 0.23447, Low MVPA: 28.9185 ± 0.25464) were included in the analysis which represents 114,536,287 Americans. MVPA was measured via accelerometry and was divided into high (44.2889 ± 0.80263 mins/day) and low (9.1269 ± 0.19560). PCBs were measured from blood collected at the mobile examination center. After controlling for race, ethnicity, gender, BMI, and weight loss within the past year, , PCB 153 (High MVPA: 0.255± 0.013 vs. Low MVPA: 0.223±0.009ng/g), PCB 170 (High MVPA: 0.049± .003 vs. Low MVPA: 0.077±0.002, ng/g), PCB 172 (High MVPA: 0.010±0.001vs. Low MVPA: 0.009±0.0003, ng/g), PCB 178 (High MVPA: 0.015 ±0.001 vs. Low MVPA: 0.012±0.001, ng/g), PCB 180 (High MVPA: 0.217± 0.009 vs. Low MVPA: 0.181±0.007, ng/g), PCB 183 (High MVPA: .020 ±0.001 vs. Low MVPA: 0.017±.001, ng/g), PCB 194 (High MVPA: 0.048 ±0.002vs. Low MVPA: 0.042± 0.002, ng/g),were significant. Thus, it appears that PCB 153, 170, 172, 178, 180, 183, 194 are significantly higher in individuals with higher levels of physical activity; although the clinical implications of such a small difference remain unknown.

Presenting Author Name/s

Ashley Middleton

Faculty Advisor/Mentor

Leryn Reynolds, Joel Harden

College Affiliation

College of Education & Professional Studies (Darden)

Presentation Type

Oral Presentation

Disciplines

Exercise Science | Kinesiology | Life Sciences

Session Title

College of Education UG Research #1

Location

Zoom

Start Date

3-19-2022 1:00 PM

End Date

3-19-2022 2:00 PM

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Mar 19th, 1:00 PM Mar 19th, 2:00 PM

The Effect of Physical Activity on Polychlorinated Biphenyls: A Pilot Study

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Polychlorinated Biphenyls (PCBs) are associated with an increased risk of cardiovascular and metabolic disease. PCBs are sequestered in adipose tissue and exercise stimulates lipolysis. However, whether PCB concentrations are altered in habitually active individuals is not well understood. Thus, the purpose of this study was to examine if individuals who participate in high levels of moderate to vigorous physical activity (MVPA) have altered levels of PCBs compared to individuals who participate in low levels of MVPA. Data from the National Health and Nutrition Examination Survey (NHANES) (2003-2004 years) was used 2,697 individuals (Age: High MVPA: 38.67 ± 0.540, Low MVPA: 50.99± 0.618) and BMI: High MVPA: 26.6212 ± 0.23447, Low MVPA: 28.9185 ± 0.25464) were included in the analysis which represents 114,536,287 Americans. MVPA was measured via accelerometry and was divided into high (44.2889 ± 0.80263 mins/day) and low (9.1269 ± 0.19560). PCBs were measured from blood collected at the mobile examination center. After controlling for race, ethnicity, gender, BMI, and weight loss within the past year, , PCB 153 (High MVPA: 0.255± 0.013 vs. Low MVPA: 0.223±0.009ng/g), PCB 170 (High MVPA: 0.049± .003 vs. Low MVPA: 0.077±0.002, ng/g), PCB 172 (High MVPA: 0.010±0.001vs. Low MVPA: 0.009±0.0003, ng/g), PCB 178 (High MVPA: 0.015 ±0.001 vs. Low MVPA: 0.012±0.001, ng/g), PCB 180 (High MVPA: 0.217± 0.009 vs. Low MVPA: 0.181±0.007, ng/g), PCB 183 (High MVPA: .020 ±0.001 vs. Low MVPA: 0.017±.001, ng/g), PCB 194 (High MVPA: 0.048 ±0.002vs. Low MVPA: 0.042± 0.002, ng/g),were significant. Thus, it appears that PCB 153, 170, 172, 178, 180, 183, 194 are significantly higher in individuals with higher levels of physical activity; although the clinical implications of such a small difference remain unknown.