Title

Accessing Biologically Important Imines and Nitrogen Heterocycles Using an Organocatalyst

Description/Abstract/Artist Statement

Nitrogen-containing heterocycles play a prominent role in a variety of biological systems and drug-like molecules. Imines play an important role in the formation of these heterocycles and commercially available starting materials include alcohols and amines and a direct oxidative transformation to form imines is highly valuable. Bobbitt salt, a bench-stable and environmentally benign oxidant, can be employed to access imines in a one-pot oxidation. Our developed method affords moderate to high yields of the desired imine product and can be further functionalized to highly valuable nitrogen heterocycles. Optimized reaction conditions allow for an environmentally safe and cost effective method to accomplish this transformation.

Presenting Author Name/s

Stephonda Lewis

Faculty Advisor/Mentor

Kyle Lambert

College Affiliation

College of Sciences

Presentation Type

Oral Presentation

Disciplines

Heterocyclic Compounds | Organic Chemicals

Session Title

Monarchs Maximizing Access to Research Careers #2

Location

Zoom

Start Date

3-19-2022 2:15 PM

End Date

3-19-2022 3:15 PM

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Mar 19th, 2:15 PM Mar 19th, 3:15 PM

Accessing Biologically Important Imines and Nitrogen Heterocycles Using an Organocatalyst

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Nitrogen-containing heterocycles play a prominent role in a variety of biological systems and drug-like molecules. Imines play an important role in the formation of these heterocycles and commercially available starting materials include alcohols and amines and a direct oxidative transformation to form imines is highly valuable. Bobbitt salt, a bench-stable and environmentally benign oxidant, can be employed to access imines in a one-pot oxidation. Our developed method affords moderate to high yields of the desired imine product and can be further functionalized to highly valuable nitrogen heterocycles. Optimized reaction conditions allow for an environmentally safe and cost effective method to accomplish this transformation.