10 - Neuro3ngaging: Neurosciences Reimagined Through Brain Diseases, Medical Education and Collaborations
Description/Abstract/Artist Statement
The Musto Laboratory investigates the cellular and molecular mechanisms underlying epilepsy and glioblastoma multiforme (GBM), with focus on inflammatory signaling as a common pathogenic denominator. Our comprehensive approach integrates human data with experimental models, utilizing pharmacological, molecular, immunohistochemical, and electrophysiological techniques. Key research initiatives include: examining CD40 ligand's role in temporal lobe epilepsy; investigating GBM-neuron interactions in tumor invasion; studying SARS-CoV-2 spike protein-triggered neuroinflammation; developing planarian models for seizure research; and defining inflammatory networks in Alzheimer's disease. Beyond biomedical investigation, the lab conducts educational research in four domains: enhancing observational skills and pattern recognition in medical training; strengthening critical thinking through neurological case studies; exploring the neurobiology of learning to augment self-directed education; and analyzing longitudinal mentorship impacts on professional development. Through this dual approach to research including strong scientific collaborations, The Musto Laboratory aims to identify novel biomarkers and innovative therapeutic targets in neurology while simultaneously advancing medical education methodologies. Our work addresses urgent unmet medical needs while preparing future clinicians with enhanced diagnostic abilities and critical thinking skills essential for effective patient care.
College Affiliation
Eastern Virginia Medical School
Presentation Type
Oral Presentation
Disciplines
Medicine and Health Sciences
10 - Neuro3ngaging: Neurosciences Reimagined Through Brain Diseases, Medical Education and Collaborations
The Musto Laboratory investigates the cellular and molecular mechanisms underlying epilepsy and glioblastoma multiforme (GBM), with focus on inflammatory signaling as a common pathogenic denominator. Our comprehensive approach integrates human data with experimental models, utilizing pharmacological, molecular, immunohistochemical, and electrophysiological techniques. Key research initiatives include: examining CD40 ligand's role in temporal lobe epilepsy; investigating GBM-neuron interactions in tumor invasion; studying SARS-CoV-2 spike protein-triggered neuroinflammation; developing planarian models for seizure research; and defining inflammatory networks in Alzheimer's disease. Beyond biomedical investigation, the lab conducts educational research in four domains: enhancing observational skills and pattern recognition in medical training; strengthening critical thinking through neurological case studies; exploring the neurobiology of learning to augment self-directed education; and analyzing longitudinal mentorship impacts on professional development. Through this dual approach to research including strong scientific collaborations, The Musto Laboratory aims to identify novel biomarkers and innovative therapeutic targets in neurology while simultaneously advancing medical education methodologies. Our work addresses urgent unmet medical needs while preparing future clinicians with enhanced diagnostic abilities and critical thinking skills essential for effective patient care.
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