24 - Cobalt catalyst utility in organic synthesis
Description/Abstract/Artist Statement
Carbon-coupling reactions are important for the addition of new functional groups for biologically relevant molecules and in key intermediates for natural product synthesis. Such synthesis commonly utilizes transition metal catalysts such as palladium, indium, and ruthenium which are costly due to low environmental abundance. Therefore, exploration of cobalt catalysts are an optimal choice due to high abundances and thus environmental sustainability. Exploration of cobalt catalysts for organic synthesis, notably allylboration and prenylation reactions, have seen substantial conversion to the desired allyl and prenyl products via a Zimmerman-Traxler transition state. This method utilizes mild conditions as well as an aqueous solvent system. The development and mechanistic aspects of the methodology will be discussed.
Faculty Advisor/Mentor
Kyle M Lambert
Faculty Advisor/Mentor Department
Chemistry and Biochemistry
College Affiliation
College of Sciences
Presentation Type
Poster
Disciplines
Organic Chemistry
24 - Cobalt catalyst utility in organic synthesis
Carbon-coupling reactions are important for the addition of new functional groups for biologically relevant molecules and in key intermediates for natural product synthesis. Such synthesis commonly utilizes transition metal catalysts such as palladium, indium, and ruthenium which are costly due to low environmental abundance. Therefore, exploration of cobalt catalysts are an optimal choice due to high abundances and thus environmental sustainability. Exploration of cobalt catalysts for organic synthesis, notably allylboration and prenylation reactions, have seen substantial conversion to the desired allyl and prenyl products via a Zimmerman-Traxler transition state. This method utilizes mild conditions as well as an aqueous solvent system. The development and mechanistic aspects of the methodology will be discussed.