Description/Abstract/Artist Statement
Magnetic particle hyperthermia (MPH) is a form of cancer treatment in which cancer cells are made more susceptible to treatments, primarily radiation, through heating. The heat is generated from exciting magnetic nanoparticles (MNPs) within an alternating magnetic field (AMF)—nanoparticles which have been injected into a tumor—and both the heating quality and imaging quality of these MNPs are determined by their magnetic properties, with the primary one being anisotropy. Magnetic nanoparticles have been introduced as both a treatment option as well as a diagnostic tool through magnetic particle imaging (MPI). When used as a diagnostic tool, MNPs act as tracers to detect tumors. We hypothesized that by adding dopants to iron oxide nanoparticles, MNPs would show improved heating and imaging. In this project, six different manganese ferrite formulations were characterized using thermal and imaging processes to further develop theranostic MPI and MPH treatments. By first performing a modified ferene-s assay protocol, the iron concentration of each MNP solution was determined. The specific loss power (SLP) of each manganese ferrite formulation was measured by performing pulsed heating with an AMF at a fixed frequency (341.25 kHz) and varying field strengths. Data from these tests were analyzed, and the SLP values of the various samples were calculated using a custom code in MATLAB. Diluted samples of each formulation were then used to perform the imaging measurements. Magnetic relaxometry measurements were taken using the MPI scanner produced by Magnetic Insight. A relaxometry curve created from these measurements was used to determine the MPI signal intensity and the MPI full width at half max (FWHM) for each formulation. From the results of the SLP calculations, it was concluded that formulations having a higher percentage of dopants yielded higher SLP values. Moreover, MPI results concluded that the addition of the dopant Zn leads to a decrease in FWHM values. Future studies of these formulations would focus on testing them at higher field strengths.
Faculty Advisor/Mentor
Dharmakeerthi Nawarathna
Faculty Advisor/Mentor Department
Electrical and Computer Engineering
College Affiliation
College of Sciences
Presentation Type
Poster
Disciplines
Nanoscience and Nanotechnology
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82 - Characterization of Manganese Ferrites for Combined MPH/MPI Treatments
Magnetic particle hyperthermia (MPH) is a form of cancer treatment in which cancer cells are made more susceptible to treatments, primarily radiation, through heating. The heat is generated from exciting magnetic nanoparticles (MNPs) within an alternating magnetic field (AMF)—nanoparticles which have been injected into a tumor—and both the heating quality and imaging quality of these MNPs are determined by their magnetic properties, with the primary one being anisotropy. Magnetic nanoparticles have been introduced as both a treatment option as well as a diagnostic tool through magnetic particle imaging (MPI). When used as a diagnostic tool, MNPs act as tracers to detect tumors. We hypothesized that by adding dopants to iron oxide nanoparticles, MNPs would show improved heating and imaging. In this project, six different manganese ferrite formulations were characterized using thermal and imaging processes to further develop theranostic MPI and MPH treatments. By first performing a modified ferene-s assay protocol, the iron concentration of each MNP solution was determined. The specific loss power (SLP) of each manganese ferrite formulation was measured by performing pulsed heating with an AMF at a fixed frequency (341.25 kHz) and varying field strengths. Data from these tests were analyzed, and the SLP values of the various samples were calculated using a custom code in MATLAB. Diluted samples of each formulation were then used to perform the imaging measurements. Magnetic relaxometry measurements were taken using the MPI scanner produced by Magnetic Insight. A relaxometry curve created from these measurements was used to determine the MPI signal intensity and the MPI full width at half max (FWHM) for each formulation. From the results of the SLP calculations, it was concluded that formulations having a higher percentage of dopants yielded higher SLP values. Moreover, MPI results concluded that the addition of the dopant Zn leads to a decrease in FWHM values. Future studies of these formulations would focus on testing them at higher field strengths.