Event Title

The Regulation of DNA Methylation by the HOXA13 gene within Glioblastoma Cells

Location

Taylor 405, Madison Union, JMU

Start Date

4-6-2019 9:00 AM

Description

Funded through a grant provided by the national Tri-Beta biology honors program, this project not only provides a potential way of controlling tumor progression, but it also delivers a possibility of how DNA methylation rates can be used to understand brain cancer. Using techniques such as human cell culture, western blotting, methylated DNA quantification, and CRISPR/CAS9, the project looks into the specific mechanism of hyper-methylation. Previously published literature linked homeobox genes to brain cancer (glioblastoma), but it was unclear why the two had a correlation. This project proposes that the missing link is the DNA methylation happening within the cells controlled by homeobox genes.

Presentation Type

Poster

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Apr 6th, 9:00 AM

The Regulation of DNA Methylation by the HOXA13 gene within Glioblastoma Cells

Taylor 405, Madison Union, JMU

Funded through a grant provided by the national Tri-Beta biology honors program, this project not only provides a potential way of controlling tumor progression, but it also delivers a possibility of how DNA methylation rates can be used to understand brain cancer. Using techniques such as human cell culture, western blotting, methylated DNA quantification, and CRISPR/CAS9, the project looks into the specific mechanism of hyper-methylation. Previously published literature linked homeobox genes to brain cancer (glioblastoma), but it was unclear why the two had a correlation. This project proposes that the missing link is the DNA methylation happening within the cells controlled by homeobox genes.