Presentations

Event Title

Crystal Structure of Glutamate--tRNA Synthase from Elizabethkingia anophelis and Elizabethkingia meningoseptica

Date

April 2021

Location

Online

Description

The United States has seen increased rates of infection for Gram-negative bacteria Elizabethkingia in the past ten years and discovering possible drugs to inhibit Elizabethkingia bacteria is of great public health importance. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of glutamate tRNA ligase from Elizabethkingia meningoseptica and Elizabethkingia anophelis. Similarities in structure and function to that of a protein with known drug inhibitors, glutamyl-tRNA synthetase GluRS from Pseudomonas aeruginosa, suggesting that these two proteins can be investigated further for drug discovery.

Presentation Type

Presentation

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Crystal Structure of Glutamate--tRNA Synthase from Elizabethkingia anophelis and Elizabethkingia meningoseptica

Online

The United States has seen increased rates of infection for Gram-negative bacteria Elizabethkingia in the past ten years and discovering possible drugs to inhibit Elizabethkingia bacteria is of great public health importance. The Seattle Structural Genomics Center for Infectious Disease (SSGCID) has determined the structures of glutamate tRNA ligase from Elizabethkingia meningoseptica and Elizabethkingia anophelis. Similarities in structure and function to that of a protein with known drug inhibitors, glutamyl-tRNA synthetase GluRS from Pseudomonas aeruginosa, suggesting that these two proteins can be investigated further for drug discovery.