Presentations

Event Title

The Impact of Oxygen Exposure and pH on Growth and Biofilm Formation Ability of Veillonella atypica, in Relation to Human Health

Date

April 2021

Location

Online

Description

Veillonella atypica is found in many microbiomes of the human body, including the gut and oral cavities. Previous studies have primarily focused on the role of V. atypica in the oral microbiome, including its association with periodontal disease and its function as an early colonizer in the development of dental biofilm. V. atypica is an extremely understudied bacteria that lives in the human microbiome and has known metabolic pathways that utilize lactate as a primary carbon source. Athletes have increased concentrations of lactate in circulation and V. atypica was found to be associated with enhanced athletic performance in endurance athletes. The aerotolerance of V. atypica was much higher than expected and the bacteria were still living after 24 hours exposure to oxygen. V. atypica was grown in BHIL broth in a pH range of 2.85 to 11.85 and grew most successfully and had greatest biofilm production in the pH range of 5.85 to 9.85. This range correlates with the pH range of the small and large intestine of the human gastrointestinal (GI) tract. Additional study on the impact of lactate concentration, aerotolerance, and biofilm contribution in the gut could provide a more definitive link between V. atypica and human health.

Presentation Type

Presentation

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The Impact of Oxygen Exposure and pH on Growth and Biofilm Formation Ability of Veillonella atypica, in Relation to Human Health

Online

Veillonella atypica is found in many microbiomes of the human body, including the gut and oral cavities. Previous studies have primarily focused on the role of V. atypica in the oral microbiome, including its association with periodontal disease and its function as an early colonizer in the development of dental biofilm. V. atypica is an extremely understudied bacteria that lives in the human microbiome and has known metabolic pathways that utilize lactate as a primary carbon source. Athletes have increased concentrations of lactate in circulation and V. atypica was found to be associated with enhanced athletic performance in endurance athletes. The aerotolerance of V. atypica was much higher than expected and the bacteria were still living after 24 hours exposure to oxygen. V. atypica was grown in BHIL broth in a pH range of 2.85 to 11.85 and grew most successfully and had greatest biofilm production in the pH range of 5.85 to 9.85. This range correlates with the pH range of the small and large intestine of the human gastrointestinal (GI) tract. Additional study on the impact of lactate concentration, aerotolerance, and biofilm contribution in the gut could provide a more definitive link between V. atypica and human health.