Date of Award

Fall 1988

Document Type

Thesis

Degree Name

Master of Science (MS)

Department

Chemistry & Biochemistry

Program/Concentration

Chemistry

Committee Director

Roy L. Williams

Committee Member

Patricia A. Pleban

Committee Member

Frank E. Scully, Jr.

Committee Member

John D. Van Norman

Call Number for Print

Special Collections LD4331.C45W36

Abstract

Drugs such as adrenoceptor antagonists and certain centrally acting agents are known to lower blood pressure and thus serve as clinically useful antihypertensive agents. Norepinephrine 4, a natural ∝-adrenoceptor agonist, is the major agent associated with increased blood pressure in the periphery. Based on a careful structure-activity comparison, a series of substituted oxazolidines, 20, 21, 22 and 23, have been designed as possible antihypertensive candidates. Specifically, 22 and 23 have been synthesized to serve as potential norepinephrine antagonists.

Preliminary evaluation of these compounds indicated that they were not antihypertensive in nature. The more active compound, 23, was subsequently evaluated for its β-agonist properties using agents such as isoproterenol 9 and a suitable S-antagonist, propranolol 40.

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DOI

10.25777/v3n6-8764

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