Myocardial ischemia can damage heart muscle and reduce the heart's pumping efficiency. This study used an ischemic swine heart model to investigate the potential for gene electro transfer of a plasmid encoding vascular endothelial growth factor for improving perfusion and, thus, for reducing cardiomyopathy following acute coronary syndrome. Plasmid expression was significantly greater in gene electro transfer treated tissue compared to injection of plasmid encoding vascular endothelial growth factor alone. Higher gene expression was also seen in ischemic versus non-ischemic groups with parameters 20 Volts (p
Original Publication Citation
Hargrave, B., Strange, R., Jr., Navare, S., Stratton, M., Burcus, N., Murray, L., . . . Heller, R. (2014). Gene electro transfer of plasmid encoding vascular endothelial growth factor for enhanced expression and perfusion in the ischemic swine heart. PLoS One, 9(12), e115235. doi: 10.1371/journal.pone.0115235
Hargrave, Barbara Y.; Strange, Robert Jr.; Navare, Sagar; Stratton, Michael; Burcus, Niculina; Murray, Len; Lundberg, Cathryn; Bulysheva, Anna A.; Li, Fanying; and Heller, Richard, "Gene Electro Transfer of Plasmid Encoding Vascular Endothelial Growth Factor for Enhanced Expression and Perfusion in the Ischemic Swine Heart" (2014). Bioelectrics Publications. 11.