Document Type

Article

Publication Date

2016

Publication Title

Inorganic Chemistry Communications

Volume

64

Pages

45-49

DOI

10.1016/j.inoche.2015.12.013

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl · 0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIᶐ which may account for the observed anti-cancer effects.

Comments

NOTE: This is the author's pre-print version of a work that was published in Inorganic Chemistry Communications. The final version was published as:

Sandhaus, S., Taylor, R., Edwards, T., Huddleston, A., Wooten, Y., Venkatraman, R., . . . Holder, A. A. (2016). A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIᶐ. Inorganic Chemistry Communications, 64, 45-49. doi:10.1016/j.inoche.2015.12.013

Available at: http://dx.doi.org/10.1016/j.inoche.2015.12.013


Original Publication Citation

Sandhaus, S., Taylor, R., Edwards, T., Huddleston, A., Wooten, Y., Venkatraman, R., . . . Holder, A. A. (2016). A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIᶐ. Inorganic Chemistry Communications, 64, 45-49. doi:10.1016/j.inoche.2015.12.013

ORCID

0000-0002-6075-9452 (Beebe), 0000-0001-9618-5297 (Holder)

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