Document Type
Article
Publication Date
2013
Publication Title
International Immunopharmacology
Volume
17
Issue
2
Pages
260-266
DOI
10.1016/j.intimp.2013.05.022
Abstract
Natural killer T cells (NKT) represent a group of CD1d-restricted T-lineage cells that provide a functional interface between innate and adaptive immune responses in infectious disease, cancer, allergy and autoimmunity. There have been remarkable advances in understanding the molecular events that underpin NKT development in the thymus and in the complex array of functions in the periphery. Most functional studies have focused on activation of T cell antigen receptors expressed by NKT cells and their responses to CD1d presentation of glycolipid and related antigens. Receiving less attention has been several molecules that are hallmarks of Natural Killer (NK) cells, but nonetheless expressed by NKT cells. These include several activating and inhibitory receptors that may fine-tune NKT development and survival, as well as activation via antigen receptors. Herein, we review the possible roles of the NK1.1 and NKG2D receptors in regulating development and function of NKT cells in health and disease. We suggest that pharmacological alteration of NKT activity should consider the potential complexities commensurate with NK1.1 and NKG2D expression
Original Publication Citation
Joshi, S. K., & Lang, M. L. (2013). Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function. International Immunopharmacology, 17(2), 260-266. doi:10.1016/j.intimp.2013.05.022
Repository Citation
Joshi, Sunil K. and Lang, Mark L., "Fine Tuning a Well-Oiled Machine: Influence of NK1.1 and NKG2D on NKT Cell Development and Function" (2013). Bioelectrics Publications. 180.
https://digitalcommons.odu.edu/bioelectrics_pubs/180
Included in
Immunology and Infectious Disease Commons, Pharmacology Commons, Pharmacy and Pharmaceutical Sciences Commons
Comments
NOTE: This is the author's post-print version of a work that was published in International Immunopharmacology. The final version was published as:
Joshi, S. K., & Lang, M. L. (2013). Fine tuning a well-oiled machine: Influence of NK1.1 and NKG2D on NKT cell development and function. International Immunopharmacology, 17(2), 260-266. doi:10.1016/j.intimp.2013.05.022
Available at: http://dx.doi.org/10.1016/j.intimp.2013.05.022