Document Type

Article

Publication Date

2020

Publication Title

Scientific Reports

Volume

10

Issue

1

Pages

5122 (1-10)

DOI

10.1038/s41598-020-62017-8

Abstract

Nanosecond Pulsed Electric Fields (nsPEF) have the potential to treat a variety of cancer types including melanoma, pancreatic and lung squamous cancers. Recent studies show that nsPEF-based cancer therapy may be improved further with the assistance of moderate heating of the target. A feedbacklooped heating system, utilizing a 980-nm fiber optic laser, was integrated into nsPEF electrodes for tumor ablation. The laser beam profile was determined to be Gaussian using a knife-edge technique. Thermal properties of the biological target were evaluated based on the treatment area, penetration depth and thermal distribution due to laser irradiation with or without nsPEF. Synergistic effects between nsPEF and the moderately elevated temperature at the target was observed, resulting in enhanced overall survival tumor regression up to 50% in the treatment of lung squamous cell cancer in mice.

Comments

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

Original Publication Citation

Hornef, J., Edelblute, C. M., Schoenbach, K. H., Heller, R., Guo, S. Q., & Jiang, C. Q. (2020). Thermal analysis of infrared irradiation-assisted nanosecond-pulsed tumor ablation. Scientific Reports, 10(1), 10 pp., Article 5122. https://doi.org/10.1038/s41598-020-62017-8

ORCID

0000-0003-1899-3859 (Heller), 0000-0002-7280-7888 (Guo), 0000-0001-7867-7773 (Schoenbach)

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