Document Type

Article

Publication Date

11-2020

Publication Title

Physics of Plasmas

Volume

27

Issue

11

Pages

1-9

DOI

10.1063/5.0020435

Abstract

Dosage control of reactive oxygen and nitrogen species (RONS) is critical to low-temperature plasma applications in cancer therapy. Production of RONS by atmospheric pressure, nonequilibrium plasmas in contact with liquid may be modulated via plasma conditions including plasma treatment time and pulse voltage and repetition frequency. In this study, a terephthalic acid-based probe was used to measure hydroxyl radicals [OHaq] in water exposed to plasma and to demonstrate that the OHag concentration increases linearly with treatment time. Fluorometric measurements of hydrogen peroxide concentration in plasma-activated water show a linear relationship between the H2O2 production rate and the pulse repetition frequency of the plasma. In vitro plasma treatment of cancer cells shows that pancreatic (Pan02) and breast (4T1-Luc) cancer cells have different sensitivities to plasma exposure. The dependence of Pan02 cell viability on plasma treatment time or pulse voltage is nonlinear. The system described here for generation and delivery of reactive oxygen species from a nanosecond pulsed plasma jet represents a promising alternative approach to cancer therapy.

Comments

Published under license by AIP Publishing. https://doi.org/10.1063/5.0020435

Original Publication Citation

Jiang, C., Sözer, E. B., Song, S., Lai, N., Vernier, P. T., & Guo, S. (2020). Modulation of ROS in nanosecond-pulsed plasma-activated media for dosage-dependent cancer cell inactivation in vitro. Physics of Plasmas, 27(11), 1-9, Article 113513. https://doi.org/10.1063/5.0020435

ORCID

0000-0002-6244-3670 (Sozer), 0000-0002-3436-289X (Lai), 0000-0003-2335-1500 (Vernier)

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