Document Type
Article
Publication Date
2022
Publication Title
Biomedicines
Volume
10
Issue
3
Pages
528 (1-18)
DOI
10.3390/biomedicines10030528
Abstract
In recent years, the emerging technology of cold atmospheric pressure plasma (CAP) has grown rapidly along with the many medical applications of cold plasma (e.g., cancer, skin disease, tissue repair, etc.). Plasma-activated liquids (e.g., culture media, water, or normal saline, previously exposed to plasma) are being studied as cancer treatments, and due to their advantages, many researchers prefer plasma-activated liquids as an alternative to CAP in the treatment of cancer. In this study, we showed that plasma-activated-saline (PAS) treatment significantly inhibited tumor growth, as compared with saline, in melanoma, and a low-pH environment had little effect on tumor growth in vivo. In addition, based on an ultra-high-performance liquid tandem chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) analysis of tumor cell metabolism, the glycerophospholipid metabolic pathway was the most susceptible metabolic pathway to PAS treatment in melanoma in vitro and in vivo. Furthermore, PAS also inhibited cell proliferation in vivo in oral tongue squamous-cell cancer and non-small-cell lung cancer. There were few toxic side effects in the three animal models, and the treatment was deemed safe to use. In the future, plasma-activated liquids may serve as a potential therapeutic approach in the treatment of cancer.
Original Publication Citation
Qi, M., Xu, D., Wang, S., Li, B., Peng, S., Li, Q., Zhang, H., Fan, R., Chen, H.-L., & Kong, M. G. (2022). In vivo metabolic analysis of the anticancer effects of plasma-activated saline in three tumor animal models. Biomedicines, 10(3), 1-18, Article 528. https://doi.org/10.3390/biomedicines10030528
Repository Citation
Qi, Miao; Xu, Dehui; Wang, Shuai; Li, Bing; Peng, Sansan; Li, Qiaosong; Zhang, Hao; Fan, Runze; Chen, Hai-Lan; and Kong, Michael G., "In Vivo Metabolic Analysis of the Anticancer Effects of Plasma-Activated Saline in Three Tumor Animal Models" (2022). Bioelectrics Publications. 325.
https://digitalcommons.odu.edu/bioelectrics_pubs/325
ORCID
0000-0001-8142-4726 (Kong)
Included in
Bioelectrical and Neuroengineering Commons, Cancer Biology Commons, Skin and Connective Tissue Diseases Commons
Comments
© 2022 by the authors.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International (CC BY 4.0) License.