Document Type

Article

Publication Date

2023

Publication Title

Histology and Histopathology

Volume

39

Issue

2

Pages

131-144 pp.

DOI

10.14670/hh-18-659

Abstract

Acute respiratory distress syndrome (ARDS) is a severe respiratory condition characterized by increased lung permeability, hyper-inflammatory state, and fluid leak into the alveolar spaces. ARDS is a heterogeneous disease, with multiple direct and indirect causes that result in a mortality of up to 40%. Due to the ongoing Covid-19 pandemic, its incidence has increased up to ten-fold. Extracellular vesicles (EVs) are small liposome-like particles that mediate intercellular communication and play a major role in ARDS pathophysiology. Indeed, they participate in endothelial barrier dysfunction and permeability, neutrophil, and macrophage activation, and also in the development of a hypercoagulable state. A more thorough understanding of the variegated and cell-specific functions of EVs may lead to the development of safe and effective therapeutics. In this review, we have collected evidence of EVs role in ARDS, revise the main mechanisms of production and internalization and summarize the current therapeutical approaches that have shown the ability to modulate EV signaling.

Rights

© The Authors 2024.

This article is licensed under a Creative Commons Attribution 4.0 International License.

Original Publication Citation

Bavuso, M., Miller, N., Sill, J. M., Dobrian, A., & Colunga Biancatelli, R. M. L. (2024). Extracellular vesicles in acute respiratory distress syndrome: Understanding protective and harmful signaling for the development of new therapeutics. Histology and Histopathology, 39(2), 131-144. https://doi.org/10.14670/hh-18-659

ORCID

0000-0002-6642-8953 (Sill), 0000-0002-1174-3876 (Biancatelli)

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