Document Type

Article

Publication Date

2024

Publication Title

Respiratory Research

Volume

25

Issue

1

Pages

390 (1-11)

DOI

10.1186/s12931-024-03022-7

Abstract

Hydrochloric acid is one of the most prevalent and hazardous chemicals. Accidental spills occur in industrial plants or during transportation. Exposure to HCl can induce severe health impairment, including acute and chronic pulmonary diseases. We have previously described the molecular, structural, and functional aspects of the development of chronic lung injury and pulmonary fibrosis caused by intratracheal instillation of HCl in mice. Although mouse models of human disease have many advantages, rodents are evolutionary far from human and exhibit significant anatomical and physiological differences. Genetic and anatomic similarities between rabbits and humans are significantly higher. Rabbit models of HCl-induced lung injury have been used sparsely to evaluate acute lung injury. In this study, for the first time, we utilized rabbits as a model of HCl-induced pulmonary fibrosis and chronic lung injury. We present molecular, histological, and functional evidence that demonstrate the utility of using this model for studying new pharmaceutics against pulmonary fibrosis.

Rights

© 2024 The authors.

This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original authors and the source, provide a link to the Creative Commons license, and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

Data Availability

Article states: "No datasets were generated or analysed during the current study."

Original Publication Citation

Solopov, P. A., Colunga Biancatelli, R. M. L., Day, T., Dimitropoulou, C., & Catravas, J. D. (2024). A novel non-rodent animal model of hydrochloric acid-induced acute and chronic lung injury. Respiratory Research, 25(1), 1-11, Article 390. https://doi.org/10.1186/s12931-024-03022-7

ORCID

0000-0002-1705-027X (Solopov), 0000-0002-1174-3876 (Colunga Biancatelli), 0000-0002-5098-295X (Catravas)

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